Why the study?
Does dopamine inhibit angiotensin-stimulated aldosterone biosynthesis in isolated bovine adrenal cells?
Population
Isolated bovine adrenal cells
Comparison
Dopamine (including 10 nM concentration) vs Basal conditions or angiotensin II stimulation…
Design
Preclinical
Authors
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May explain dopaminergic effects on aldosterone in experimental models; leaves open translation to human cardiovascular therapy.
Does dopamine inhibit angiotensin-stimulated aldosterone biosynthesis in isolated bovine adrenal cells?
In vitro studies demonstrate that dopamine directly inhibits the late phase of angiotensin-stimulated aldosterone biosynthesis, offering a mechanistic explanation for the in vivo effects of dopaminergic agents.
Kenna et al. (1979) studied this question.
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