Population
In vitro model using human plasma and semipurified renin substrate
Design
Preclinical
Authors
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May support feedback inhibition of angiotensin generation; animal data leaves open human physiological relevance.
Human des-angiotensin I renin substrate acts as a competitive inhibitor of the renin reaction, which may have physiological significance for feedback inhibition of angiotensin I generation.
Barrett et al. (1979) studied this question.
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