Population
rat brain homogenates
Comparison
lowering the tissue concentration of monovalent… vs normal preparations
Design
Preclinical
Authors
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Requires caution in ganglioside extraction under altered cations or pH; leaves open relevance to human cardiovascular tissues.
Lowering tissue pH or decreasing monovalent cations allows electrostatic association between negatively charged gangliosides and positively charged proteins, reducing extractability.
Matthew W. Spence (1969) studied this question.
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