Population
HeLa cells and primary chicken embryo (CE) cells
Comparison
Infection or superinfection with poliovirus vs Infection with Sindbis virus alone
Design
Preclinical
Follow-up
24 hours
Authors
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These in vitro findings are hypothesis-generating; should not change practice and require in vivo confirmation.
In HeLa cells, poliovirus superinfection inhibits Sindbis virus replication by blocking viral protein synthesis at the translational level.
Sreevalsan et al. (1974) studied this question.
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