What question did this study set out to answer?

To determine whether right coronary pressure modulates right ventricular systolic stiffness and accounts for pressure-dependent changes in myocardial oxygen consumption.

April 1, 1999Cardiovascular ResearchOpen Access

Right coronary pressure modulates right ventricular systolic stiffness and oxygen consumption

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Why the study?

Does lowering right coronary pressure affect right ventricular systolic stiffness and oxygen consumption in an anesthetized dog model?

Population

8 dogs anesthetized with pentobarbital and fentanyl

Comparison

Lowering right coronary pressure from baseline… vs Baseline right coronary pressure

Design

Preclinical

Authors

XBXiaoming BianDalian Medical University

Discussion

Member takes

Implication

Findings in canine model suggest pressure-dependent RV stiffness modulation; human validation required before clinical consideration.

Key Points

To determine whether right coronary pressure modulates right ventricular systolic stiffness and accounts for pressure-dependent changes in myocardial oxygen consumption.
Conducted an interventional physiological study in 8 anesthetized dogs by lowering right coronary pressure from baseline to 30 mmHg in 10 mmHg increments.
Measured myocardial segment length and isometric developed force to calculate systolic myocardial stiffness from the ejection force-length slope, alongside myocardial oxygen consumption.
Decreasing right coronary pressure from 120 to 40 mmHg linearly reduced coronary blood flow, maximum developed force, systolic stiffness, and myocardial oxygen consumption while preserving segment shortening length.
Lowering pressure from 40 to 30 mmHg caused marked reductions in shortening length and peak contractility (RV dp/dtmax) alongside significant increases in right atrial pressure and end-diastolic length.
Right ventricular systolic stiffness measured 22% of left ventricular values at 100 mmHg perfusion pressure and showed a less steep relationship with coronary pressure.

Structured PICO

Does lowering right coronary pressure affect right ventricular systolic stiffness and oxygen consumption in an anesthetized dog model?

Population

8 dogs anesthetized with pentobarbital and fentanyl

Intervention

Lowering right coronary pressure (RCP) from baseline to 30 mmHg in 10 mmHg steps by adjusting an occluder on the proximal right coronary artery

Comparator

Baseline right coronary pressure

Outcome

Right ventricular systolic stiffness (slope of the force-length curve during ejection period, delta F/delta SL) and myocardial oxygen consumption (MVO2)surrogate

Reductions in right coronary pressure lead to a linear decrease in right ventricular systolic stiffness, which preserves stroke work and reduces oxygen demand to prevent ischemia.

Cite This Study

Xiaoming Bian (1999) studied this question.

synapsesocial.com/papers/6a8737f73d239a2773cf8867 https://doi.org/10.1016/s0008-6363(98)00288-0

Topics

Women and heart disease

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Ask AI

Bookmark

Right coronary pressure modulates right ventricular systolic stiffness and oxygen consumption

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Right coronary pressure modulates right ventricular systolic stiffness and oxygen consumption

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider