June 1, 1989AJP Heart and Circulatory Physiology

Effects of hydrodynamic forces on coronary production of prostacyclin and purines

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Population

Isolated rabbit hearts

Comparison

Variations in coronary flow rate, perfusion… vs Basal conditions or steady flow at the same rate

Design

Preclinical

Authors

EKEwa Karwatowska‐ProkopczukPreventive Cardiology GCGiovanni CiabattoniUniversità Cattolica del Sacro Cuore AWA WennmalmSahlgrenska University Hospital

Discussion

Member takes

Implication

Pressure-induced prostacyclin release in isolated hearts warrants no clinical change; leaves open its role in human coronary regulation.

Structured PICO

Population

Isolated rabbit hearts

Intervention

Variations in coronary flow rate (25, 50, and 100% increases), perfusion pressure (25, 50, and 100% increases), perfusate Ca2+ reduction by 50%, administration of quinacrine (1 microM), and pulsatile flow

Comparator

Basal conditions or steady flow at the same rate

Outcome

Efflux rates of 6-ketoprostaglandin F1 alpha (6-keto-PGF1 alpha) and purinessurrogate

Increased coronary pressure activates a specific, calcium- and phospholipase-independent mechanism for prostacyclin production in the isolated rabbit heart.

Cite This Study

Karwatowska‐Prokopczuk et al. (1989) studied this question.

synapsesocial.com/papers/6a87c301f455bdf6826c865f https://doi.org/10.1152/ajpheart.1989.256.6.h1532

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Effects of hydrodynamic forces on coronary production of prostacyclin and purines

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of hydrodynamic forces on coronary production of prostacyclin and purines

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider