Why the study?
Does small-plaque rhinovirus type 15 inoculum cause more illness compared to large-plaque inoculum in volunteers?
Population
75 volunteers (35 in initial passage study, 40 in purified plaque study)
Comparison
"Purified" small-plaque rhinovirus type 15… vs "Purified" large-plaque rhinovirus type 15…
Design
Other
Authors
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Small-plaque rhinovirus linked to more illness without changing infection rates; hypothesis-generating for plaque size as attenuation marker.
Does small-plaque rhinovirus type 15 inoculum cause more illness compared to large-plaque inoculum in volunteers?
Plaque size may serve as an in vitro marker of attenuation of illness production by rhinoviruses.
Douglas et al. (1974) studied this question.
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