Population
Mouse model of bleomycin-induced pulmonary fibrosis, pulmonary hypertension, and right ventricular failure
Comparison
In vitro stimulation of the α1A-adrenergic… vs Wild-type nonfailing right ventricle
Design
Preclinical
Authors
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α1A agonism may augment failing RV force; leaves open clinical translation from this animal model.
Upregulation of α1-adrenergic receptor inotropy in failing right ventricular myocardium is mediated by the α1A-subtype and opposed by the α1B-subtype, suggesting α1A as a potential therapeutic target.
Cowley et al. (2015) studied this question.
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