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January 1, 2022ClinicsOpen Access

Inhibition of Toll-like Receptor-4 expression for amelioration of myocardial injury in diabetes: A meta-analysis

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Why the study?

The study was conducted to understand the relationship between the inhibition of Toll-Like Receptor-4 (TLR4) expression levels and diabetic myocardial injury.

Does inhibition of TLR4 expression improve myocardial injury in diabetic models?

Comparison

Inhibition of TLR4 expression vs controls

Design

Meta-analysis

Authors

JYJinxin YuanXYXingwen Yin

Discussion

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Overview

Supports TLR4 inhibition as therapeutic target in diabetic cardiomyopathy; extends preclinical evidence but requires clinical trials.

Structured PICO

Does inhibition of TLR4 expression improve myocardial injury in diabetic models?

P
Population
9 publications studying diabetic myocardial injury/diabetic cardiomyopathy models
I
Intervention
Inhibition of Toll-Like Receptor-4 (TLR4) expression
C
Comparator
Control (diabetic models without TLR4 inhibition)
O
Outcome
Heart Weight/Body Weight (HW/BW) index, Left Ventricular Systolic Pressure (LVSP), and Left Ventricular End-Diastolic Pressure (LVEDP)surrogate

Inhibition of TLR4 expression improves cardiac impairment in diabetic cardiomyopathy models, highlighting it as a potential novel therapeutic target.

Cite This Study

Yuan et al. (2022) studied this question.

synapsesocial.com/papers/6a87e09302f504243ce96ac7https://doi.org/10.1016/j.clinsp.2022.100137
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systemic Delivery of siRNA Specific for Silencing TLR4 Gene Expression Reduces Diabetic Cardiomyopathy in a Mouse Model of Streptozotocin-Induced Type 1 Diabetes2020 · 23 citations
  2. 2TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes2012 · 98 citations
  3. 3Hyperinsulinemia Down-Regulates TLR4 Expression in the Mammalian Heart2014 · 4 citations
  4. 4TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway2024 · 4 citations
  5. 5Loss of toll-like receptor 4 ameliorates cardiovascular dysfunction in aged mice2021 · 16 citations