Population
Pressurized rat mesenteric small arteries (50 mmHg) and alpha-toxin-permeabilized preparations
Comparison
Stimulation with U46619, endothelin-1, or… vs Comparison between the different agonists
Design
Preclinical
Authors
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Caution against extrapolating rodent mesenteric findings to patients; leaves open calcium sensitization's role in human vasomotor patterns.
Receptor-coupled constriction in mesenteric arteries involves periodic smooth muscle calcium waves, and varied calcium-sensitizing actions of agonists may determine tonic versus phasic vessel responses.
Shaw et al. (2004) studied this question.
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