Why the study?
Do locally infused angiotensin I and II cause vasoconstriction in human peripheral vessels, and is this dependent on local converting enzyme activity?
Do locally infused angiotensin I and II cause vasoconstriction in human peripheral vessels, and is this dependent on local converting enzyme activity?
The study provides evidence for the local presence of converting enzyme in human peripheral arteries and veins by demonstrating that a converting enzyme inhibitor blocks the vasoconstrictive effects of angiotensin I but not angiotensin II.
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Supports local vascular converting enzyme in humans; leaves open its role in hypertension or ACE inhibitor efficacy.
Collier et al. (1974) studied this question.
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