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November 24, 1998Proceedings of the National Academy of SciencesOpen Access

PI 3-kinase enhances myogenic differentiation and increases muscle-specific proteins, whereas its inhibition interferes with myogenesis.

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Population

Cultures of chicken-embryo myoblasts

Design

Preclinical

Authors

BJBing‐Hua JiangJZJenny Z. ZhengPVPeter K. Vogt

Discussion

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Overview

No immediate clinical implications for muscle disorders; leaves open PI 3-kinase as a myogenesis regulator for human studies.

Structured PICO

P
Population
Cultures of chicken-embryo myoblasts
I
Intervention
Expression of oncogene p3k (constitutively active PI 3-kinase) or inhibition of PI 3-kinase activity with LY294002 or dominant-negative mutants
O
Outcome
Myogenic differentiation (size of myotubes and levels of muscle-specific proteins MyoD, myosin heavy chain, creatine kinase, and desmin)surrogate

PI 3-kinase acts as an upstream mediator that is both necessary and rate-limiting for the process of myogenesis and the expression of muscle-specific genes.

Cite This Study

Jiang et al. (1998) studied this question.

synapsesocial.com/papers/6a87ed325ed0ab632b49029ahttps://doi.org/10.1073/pnas.95.24.14179
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