Why the study?
Does left ventricular diastolic volume influence nonmechanical O2 consumption in isolated rabbit hearts?
Population
16 excised isovolumically contracting red blood cell-perfused rabbit ventricles
Comparison
High left ventricular volume during infusion of… vs Low left ventricular volume during infusion of…
Design
Preclinical
Authors
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No volume effect on nonmechanical VO2 in isolated hearts; leaves open relevance to in vivo energetics or other species.
Does left ventricular diastolic volume influence nonmechanical O2 consumption in isolated rabbit hearts?
In isolated rabbit hearts, left ventricular diastolic volume does not significantly affect nonmechanical energy consumption over a physiological range of LV end-diastolic pressure.
Higashiyama et al. (1994) studied this question.
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