Population
Perfused guinea pig hearts
Design
Preclinical
Authors
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Questions direct Ca2+ effects on cardiac PDC; leaves open workload-mediated mechanisms for validation in higher models.
In perfused guinea pig hearts, calcium-induced stimulation of the pyruvate dehydrogenase complex appears secondary to increased myocardial energy utilization rather than a direct effect of calcium.
Bünger et al. (1984) studied this question.
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