Why the study?
Does digoxin prevent ouabain and high salt intake-induced hypertension in Wistar rats?
Population
Wistar rats with or without chronic sinoaortic denervation (SAD) or sham surgery
Comparison
Digoxin or intracerebroventricular antibody Fab… vs Ouabain plus high salt intake, or high salt alone
Design
Preclinical
Follow-up
up to 14 days
Authors
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Supports central ouabain antagonism in rodent salt-hypertension models; leaves open any human therapeutic relevance.
Does digoxin prevent ouabain and high salt intake-induced hypertension in Wistar rats?
Digoxin acts centrally to prevent the sympathoexcitatory and pressor effects of increased brain ouabain or exogenous ouabain, thereby preventing high salt-induced hypertension in rats.
Huang et al. (1999) studied this question.
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