Key result
Angiotensin-converting enzyme (ACE) polymorphism was not associated with premature MI, though the DD genotype was more prevalent among hypertensive vs non-hypertensive patients (62.5% vs 35.6%, p=0.01).
Why the study?
Is the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism associated with the development of myocardial infarction in patients ≤ 35 years of age?
Case-Control (n=341)
Is the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism associated with the development of myocardial infarction in patients ≤ 35 years of age?
The ACE I/D polymorphism is not associated with premature myocardial infarction in very young patients, which may be related to the low prevalence of hypertension in this population.
Does not support ACE genotyping for premature MI risk in young adults; leaves open DD genotype effects in hypertension for prospective study.
We examined whether angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism is associated with the development of myocardial infarction (MI) at < or = 35 years of age. The study sample consisted of 201 patients with premature MI and 140 age- and sex-matched healthy individuals. No difference was found in the distribution of ACE genotypes between the patients and controls. A higher prevalence of the DD genotype among hypertensives was found compared with the non-hypertensive patients (62.5% vs 35.6%, p = 0.01). ACE polymorphism is not associated with the development of premature MI and this might be due to the low prevalence of hypertension in young coronary patients.
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Rallidis et al. (2009) conducted a case-control in Premature myocardial infarction (n=341). Angiotensin-converting enzyme (ACE) insertion/deletion polymorphism vs. Healthy controls was evaluated on Development of myocardial infarction at ≤35 years of age. Angiotensin-converting enzyme (ACE) polymorphism was not associated with premature MI, though the DD genotype was more prevalent among hypertensive vs non-hypertensive patients (62.5% vs 35.6%, p=0.01).
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