March 1, 1962Journal of HygieneOpen Access

Concentration and partial purification of poliomyelitis viruses

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Population

Three types of live or formalin-inactivated poliomyelitis viruses

Design

Preclinical

Authors

Discussion

May aid poliovirus vaccine manufacturing; leaves open translation from animal models to clinical use.

Population

Three types of live or formalin-inactivated poliomyelitis viruses

Intervention

Concentration and partial purification using AlPO4 adsorption (0.1-0.2 mg/ml) at pH ~5 and re-elution at pH 7-8

Outcome

Concentration yield and elimination of extraneous proteinsurrogate

Describes a method for concentrating and purifying poliomyelitis viruses using AlPO4 adsorption and elution.

K. H. Fantes (1962) studied this question.

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