Key result
Concentration of live poliovirus by about 1,000-fold and formalinized vaccine by over 100-fold was achieved using bivalent cations like cobalt chloride with negligible losses.
Why the study?
A simple and efficient method for concentration of live and formaldehyde-inactivated poliovirus preparations was needed.
Design
Other
Authors
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May enable efficient poliovirus vaccine prep; leaves open translation to clinical manufacturing.
Grossowicz et al. (1960) studied Poliovirus preparations. Concentration using bivalent cations (cobalt chloride) was evaluated on Concentration of live and formaldehyde-inactivated poliovirus. Concentration of live poliovirus by about 1,000-fold and formalinized vaccine by over 100-fold was achieved using bivalent cations like cobalt chloride with negligible losses.