September 1, 1932The Journal of Experimental MedicineOpen Access

Experiments on the Purification and Concentration of the Virus of Poliomyelitis

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Population

Poliomyelitis virus

Design

Preclinical

Authors

ASAlbert B. SabinRockefeller Foundation

Discussion

Member takes

Implication

Supports virus concentration methods in animal models; leaves open chemical characterization and human applications.

Structured PICO

Population

Poliomyelitis virus

Intervention

Adsorption with alumina gel C at acid pH, elution at alkaline pH with M/15 Na(2)HPO(4), washing with M/5 NaCl-M/15 KH(2)PO(4), and distillation in vacuo

Outcome

Purification and concentration of the virus (minimal effective dose, nitrogen content, and chemical reactions)surrogate

The study demonstrates a method for purifying and concentrating the poliomyelitis virus using alumina gel C, facilitating future chemical and immunological studies.

Cite This Study

Albert B. Sabin (1932) studied this question.

synapsesocial.com/papers/6a95c8e2e844cd4f5c48f86c https://doi.org/10.1084/jem.56.3.307

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Experiments on the Purification and Concentration of the Virus of Poliomyelitis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Experiments on the Purification and Concentration of the Virus of Poliomyelitis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider