Key result
In patients undergoing elective mitral valve replacement, mean pulmonary artery pressure decreased significantly over the first 24 hours postoperatively in both those with mild and severe pulmonary arterial hypertension.
Why the study?
Does elective mitral valve replacement safely improve early hemodynamic parameters in patients with severe pulmonary artery hypertension compared to those with mild pulmonary artery hypertension?
Population
45 consecutive adult patients who were candidates for elective mitral valve replacement. Patients were…
Comparison
Elective mitral valve replacement using standard… vs Patients with mild PAH undergoing the same…
Design
Cohort
Follow-up
24 hours postoperatively
Authors
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Similar early mPAP reduction after mitral valve replacement occurs in severe pulmonary hypertension; hypothesis-generating and needs randomized confirmation before practice change.
Observational (n=45)
No
Does elective mitral valve replacement safely improve early hemodynamic parameters in patients with severe pulmonary artery hypertension compared to those with mild pulmonary artery hypertension?
Absolute Event Rate: 46.1% vs 32.5%
p-value: p=<0.05
Mitral valve replacement is safe and effectively reduces pulmonary artery pressure within 24 hours in patients with severe pulmonary artery hypertension, challenging the notion that severe PAH is a contraindication for surgery.
Bayat et al. (2012) conducted an observational in Mitral valve disease with pulmonary arterial hypertension (n=45). Severe pulmonary arterial hypertension vs. Mild pulmonary arterial hypertension was evaluated on Mean pulmonary artery pressure (PAP) at 24 hours post-operation (p=<0.05). In patients undergoing elective mitral valve replacement, mean pulmonary artery pressure decreased significantly over the first 24 hours postoperatively in both those with mild and severe pulmonary arterial hypertension.
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