Key result
Intensified multifactorial intervention significantly reduced urinary albumin to creatinine ratio (1228 vs 2340 mg/g-cr, P<0.05) and blood pressure in diabetic patients with overt nephropathy.
Why the study?
Does an intensified multifactorial intervention (tight glucose regulation, valsartan, fluvastatin) improve ambulatory BP profile and renal function in hypertensive type 2 diabetic patients with overt nephropathy?
Does an intensified multifactorial intervention (tight glucose regulation, valsartan, fluvastatin) improve ambulatory BP profile and renal function in hypertensive type 2 diabetic patients with overt nephropathy?
Intensified multifactorial intervention including valsartan and fluvastatin improves blood pressure profiles and reduces albuminuria without altering eGFR in patients with diabetic nephropathy.
Answers are grounded in this paper and cite their sources.
May support intensified intervention for albuminuria in diabetic nephropathy; leaves open randomized confirmation before practice change.
Accumulating evidence has shown that diabetic patients are increasing in number, and renal and cardiovascular complications are the most common cause of death in diabetic patients. Thus, it would be of considerable value to identify the mechanisms involved in the progression of renal impairment and cardiovascular injury associated with diabetes. Recent evidence also indicated that multifactorial intervention is able to reduce the risk of cardiovascular disease and death among patients with diabetes and microalbuninuria. In this pilot study, we examined the effects of intensified multifactorial intervention, with tight glucose regulation and the use of valsartan and fluvastatin on ambulatory blood pressure (BP) profile, estimated glomerular filtration rate (eGFR), and urinary albumin to creatinine ratio (UACR), in 20 hypertensive patients (16 male and 4 female) with type 2 diabetes mellitus and overt nephropathy. After 12 months of intensified treatment, office BP, fasting plasma glucose (FPG), and low-density lipoprotein cholesterol (LDLC) were significantly decreased compared to baseline (systolic blood pressure (SBP), 130 ± 2 vs. 150 ± 1 mmHg; diastolic blood pressure (DBP), 76 ± 1 vs. 86 ± 1 mmHg; FPG, 117 ± 5 vs. 153 ± 7 mg/dl; LDLC, 116 ± 8 vs. 162 ± 5 mg/dl, P < 0.0001). Also, compared to the baseline values, the daytime and nighttime ambulatory BP and short-term BP variability were significantly decreased after 12 months. Furthermore, while eGFR was not altered (44.3 ± 5.1 vs. 44.3 ± 6.5 ml/min/1.73 m(2), not significant (NS)), UACR showed a significant reduction after 12 months of intensified treatment (1228 ± 355 vs. 2340 ± 381 mg/g-cr, P < 0.05). These results suggest that the intensified multifactorial intervention is able to improve ambulatory BP profile, preserve renal function, and reduce urinary albumin excretion in type 2 diabetic hypertensive patients with overt nephropathy.
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Kanaoka et al. (2011) studied Hypertensive type 2 diabetes mellitus with overt nephropathy (n=20). Intensified multifactorial intervention (tight glucose regulation, valsartan, fluvastatin) vs. Baseline was evaluated on Urinary albumin to creatinine ratio (UACR) (p=<0.05). Intensified multifactorial intervention significantly reduced urinary albumin to creatinine ratio (1228 vs 2340 mg/g-cr, P<0.05) and blood pressure in diabetic patients with overt nephropathy.
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