Participation of stretch-activated channels in electrocardiographic changes and arrhythmias during early phase of acute coronary occlusion.

Shunsuke Takagi; Toshihisa Miyazaki; Yoshiko Furukawa; Shinji Ito; Kazunori Moritani; Shunichiro Miyoshi; Megumi Shimada; Hideo Mitamura; Satoshi Ogawa

doi:10.5105/jse.18.459

January 1, 1998Japanese Journal of ElectrocardiologyOpen Access

Participation of stretch-activated channels in electrocardiographic changes and arrhythmias during early phase of acute coronary occlusion.

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Why the study?

Does gadolinium prevent ischemia-induced QTI shortening, ST elevation, and arrhythmias in a canine model of acute coronary occlusion?

Structured PICO

Does gadolinium prevent ischemia-induced QTI shortening, ST elevation, and arrhythmias in a canine model of acute coronary occlusion?

P

Population

29 adult mongrel dogs (14-30 kg), anesthetized, open-chest model of acute coronary occlusion (LAD occlusion for 5 minutes).

I

Intervention

Gadolinium (Gd3+) 500 μmol and 2,500 μmol administered into the left atrium before occlusion, with or without glibenclamide (0.15 mg/kg) IV.

C

Comparator

Control coronary occlusion without drug administration in the same dogs.

O

Outcome

Local repolarization time (QTI) and ST segment elevation measured by epicardial mapping at 1 and 5 minutes after coronary occlusion.surrogate

Activation of stretch-activated channels due to local wall motion abnormalities immediately after acute coronary occlusion contributes to QTI shortening, ST elevation, and arrhythmogenesis independently of KATP channels.

Limitations

Effect of Gd3+ on QTI shortening was not observed at 5 minutes post-occlusion.
Recording system limitations prevented correlating the exact time course of bulging and ST changes.
Toxicity of Gd3+ limits clinical application.

Implication

Gadolinium effects in canine ischemia do not inform clinical care; leaves open human studies on ECG changes during occlusion.

Discussion

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Cite This Study

Takagi et al. (1998) studied this question.

synapsesocial.com/papers/6a885f91010a27dee4770b2f https://doi.org/10.5105/jse.18.459

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Participation of stretch-activated channels in electrocardiographic changes and arrhythmias during early phase of acute coronary occlusion.

Structured PICO

Limitations

Implication

Discussion

Cite This Study

Participation of stretch-activated channels in electrocardiographic changes and arrhythmias during early phase of acute coronary occlusion.

Structured PICO

Limitations

Implication

Discussion

Cite This Study

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