Left Atrial Enlargement and NT-proBNP as Predictors of Sudden Cardiac Death in Patients with Heart Failure
Why the study?
Do indexed LA size and NT-proBNP levels predict sudden cardiac death in patients with heart failure due to systolic dysfunction?
Population
494 patients with established heart failure (HF) due to systolic dysfunction
Comparison
Indexed LA size >26 mm/m2 and NT-proBNP >908 ng/L vs Indexed LA size <=26 mm/m2 and NT-proBNP <=908…
Design
Cohort
Follow-up
942+/-323 days
Authors
Discussion
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Member takes
Implication
May aid SCD risk stratification in systolic HF; hypothesis-generating and requires prospective validation before guiding decisions.
Structured PICO
Do indexed LA size and NT-proBNP levels predict sudden cardiac death in patients with heart failure due to systolic dysfunction?
P
Population
494 patients with established heart failure (HF) due to systolic dysfunction
I
Intervention
Indexed LA size >26 mm/m2 and NT-proBNP >908 ng/L
C
Comparator
Indexed LA size <=26 mm/m2 and NT-proBNP <=908 ng/L
O
Outcome
Sudden cardiac death (SCD)hard clinical
The combination of indexed left atrial size and NT-proBNP levels provides strong prognostic value for predicting sudden cardiac death in patients with systolic heart failure.
Cite This Study
Bayés‐Genís et al. (2007) studied this question.