Why the study?
Does a single 10 ml injection of poliomyelitis vaccine produce rapid antibodies in persons who have not completed a 3-dose schedule?
Does a single 10 ml injection of poliomyelitis vaccine produce rapid antibodies in persons who have not completed a 3-dose schedule?
A single 10 ml injection of poliomyelitis vaccine was investigated for rapid production of antibodies.
Answers are grounded in this paper and cite their sources.
Single 10-ml polio vaccine injection may enable rapid antibodies; hypothesis-generating for incomplete schedules and requires prospective confirmation.
OLIOMYELITIS vaccine has been shown to be effective in the prevention of paralytic poliomyelitis when administered in 3 1-ml. doses over three months, as in the 1954 field trial,1 or currently in 3 doses over seven months.2 Under certain circumstances it would be desirable to provide such immunity rapidly for persons who have not completed a 3-dose immunization schedule.It is the purpose of this paper to record the rapid production of antibodies in persons given a single injection of 10 ml. of poliomyelitis vaccine produced in 1958.Materials and MethodsThree groups were used in the study. The first . . .
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Baron et al. (1959) studied this question.
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