Why the study?
Does remifentanil IV PCA provide safe and effective postoperative pain control compared to fentanyl IV PCA in patients undergoing cardiac surgery?
Does remifentanil IV PCA provide safe and effective postoperative pain control compared to fentanyl IV PCA in patients undergoing cardiac surgery?
High-dose remifentanil IV PCA (4 μg/kg/h) provides superior postoperative pain control compared to standard fentanyl IV PCA after cardiac surgery, without causing clinically significant respiratory or hemodynamic compromise.
High-dose remifentanil IV PCA warrants consideration for post-cardiac surgery analgesia; extends RCT evidence on optimized opioid PCA regimens in this population.
Background: For rapid onset and predictable elimination half life, remifentanil may be suitable for patients undergoing cardiac surgery with unstable vital sign and decreased metabolism. We evaluated the efficacy, safety and proper dosage of intravenous patient-controlled analgesia (IV PCA) using remifentanil in patients undergoing cardiac surgery.
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Kim et al. (2007) studied this question.
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