Inhibition of nitric oxide with L-NMMA causes exaggerated natriuresis and diuresis in spontaneously hypertensive rats without significant changes in mean arterial pressure or renal interstitial hydrostatic pressure.
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Exaggerated natriuresis after nitric oxide inhibition in SHR occurs independently of pressure; hypothesis-generating for hypertension mechanisms and leaves open human translation.
Ali A. Khraibi (1994) studied this question.
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