August 1, 1994Journal of Cardiovascular Pharmacology

Effects of Nω-Monomethyl-L-Arginine on Short-Term RR Interval and Systolic Blood Pressure Oscillations

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Population

Conscious rats

Design

Preclinical

Authors

JCJuan CorderoUniversidad de La Sabana JGJulián J. GonzálezUniversidad de La Laguna MFManuel FeriaTecnologie Avanzate (Italy)

Discussion

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Implication

Does not support clinical application; extends preclinical evidence on nitric oxide modulation of autonomic oscillations in rats.

Structured PICO

Population

Conscious rats

Intervention

Nω-monomethyl-L-arginine (L-NMMA) infused intravenously at 1.2 mg/kg/min

Outcome

RR interval and systolic blood pressure (SBP) variability measured by spectral analysissurrogate

In conscious rats, inhibition of endothelium-derived nitric oxide with L-NMMA alters autonomic nervous system activity, leading to changes in short-term RR interval and systolic blood pressure oscillations.

Cite This Study

Cordero et al. (1994) studied this question.

synapsesocial.com/papers/6a8bf66a3458abf7cbc5d6d5 https://doi.org/10.1097/00005344-199424020-00019

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Effects of Nω-Monomethyl-L-Arginine on Short-Term RR Interval and Systolic Blood Pressure Oscillations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of Nω-Monomethyl-L-Arginine on Short-Term RR Interval and Systolic Blood Pressure Oscillations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider