Key result
Inhibition of NO synthase with L-NMMA augmented supine blood pressure by 7% but did not affect short-term blood pressure variability or baroreflex function during head-up tilt.
Why the study?
Does NO synthase inhibition with L-NMMA affect short-term blood pressure variability and baroreflex function during head-up tilt in healthy subjects?
Population
8 healthy subjects
Comparison
Intravenous infusion of L-NMMA vs Baseline measurements before L-NMMA infusion in…
Authors
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NO inhibition raises resting BP without altering variability or baroreflex in healthy subjects; leaves open its dynamic role in patients.
Does NO synthase inhibition with L-NMMA affect short-term blood pressure variability and baroreflex function during head-up tilt in healthy subjects?
Inhibition of NO synthase does not affect short-term blood pressure variability or baroreflex function in humans, suggesting NO's role is primarily in controlling steady-state vascular tone rather than dynamic regulation.
Zhang et al. (2002) studied Healthy (n=8). L-NMMA vs. Baseline (before L-NMMA) was evaluated on Blood pressure and R-R interval variability. Inhibition of NO synthase with L-NMMA augmented supine blood pressure by 7% but did not affect short-term blood pressure variability or baroreflex function during head-up tilt.
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