August 1, 1994Journal of Cardiovascular Pharmacology

Effects of Nω-Monomethyl-L-Arginine on Short-Term RR Interval and Systolic Blood Pressure Oscillations

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Population

Conscious rats

Design

Preclinical

Authors

JCJuan CorderoUniversidad de La Sabana JGJulián J. GonzálezUniversidad de La Laguna MFManuel FeriaTecnologie Avanzate (Italy)

Discussion

Member takes

Implication

These rat findings extend mechanistic insight into nitric oxide and autonomic spectra; leaves open human translation and clinical relevance.

Structured PICO

Population

Conscious rats

Intervention

N omega-monomethyl-L-arginine (L-NMMA) infused intravenously (i.v.) at 1.2 mg/kg/min

Outcome

RR interval and systolic blood pressure (SBP) variability measured by spectral analysissurrogate

Inhibition of nitric oxide synthesis with L-NMMA in conscious rats alters autonomic regulation, increasing vagal activity and decreasing sympathetic activity.

Cite This Study

Cordero et al. (1994) studied this question.

synapsesocial.com/papers/6a8bf66a3458abf7cbc5d6d6 https://doi.org/10.1097/00005344-199408000-00019

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Implication

These rat findings extend mechanistic insight into nitric oxide and autonomic spectra; leaves open human translation and clinical relevance.

Effects of Nω-Monomethyl-L-Arginine on Short-Term RR Interval and Systolic Blood Pressure Oscillations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of Nω-Monomethyl-L-Arginine on Short-Term RR Interval and Systolic Blood Pressure Oscillations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider