Why the study?
Does intravenous L-NMMA alter arterial blood pressure variability in healthy subjects?
Population
8 healthy subjects
Comparison
Intravenous infusion of N-monomethyl-L-arginine vs Baseline (before L-NMMA infusion)
Follow-up
6 minutes per recording
Authors
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NO inhibition elevates mean BP without altering variability in healthy subjects; leaves open its role in buffering oscillations in disease.
Does intravenous L-NMMA alter arterial blood pressure variability in healthy subjects?
Nitric oxide regulates steady-state arterial pressure but does not appear to buffer dynamic blood pressure oscillations in humans.
Cooke et al. (2002) studied this question.
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