Why the study?
Do antioxidants prevent angiotensin II-induced aortic rupture in aged ApoE-deficient mice?
Do antioxidants prevent angiotensin II-induced aortic rupture in aged ApoE-deficient mice?
Antioxidants fail to protect against Ang II-induced aortic rupture in aged ApoE-deficient mice, contrasting with previous findings in younger mice and suggesting distinct pathological features from human abdominal aortic aneurysms.
Does not support antioxidant use for AAA; leaves open age-specific oxidative stress mechanisms distinct from prior younger-mouse models.
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Jiang et al. (2007) studied this question.
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