Key result
Male rats of both SHRSP and WKY strains exhibited impaired middle cerebral artery myogenic reactivity compared with females (P<0.05), with male SHRSP also showing increased vascular stiffness.
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May indicate sex-specific cerebrovascular vulnerability in hypertension models; leaves open translation to human stroke risk.
p-value: p=<0.05
Ibrahim et al. (2005) studied Hypertension. Male sex and SHRSP strain vs. Female sex and WKY strain was evaluated on Myogenic reactivity of middle cerebral arteries (p=<0.05). Male rats of both SHRSP and WKY strains exhibited impaired middle cerebral artery myogenic reactivity compared with females (P<0.05), with male SHRSP also showing increased vascular stiffness.
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