January 1, 1988AJP Heart and Circulatory Physiology

Spontaneous vasomotion in pressurized cerebral arteries from genetically hypertensive rats

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Population

Resistance-sized branches of posterior cerebral arteries from Wistar-Kyoto, spontaneously hypertensive…

Comparison

Stepwise increase in intravascular pressure and… vs Comparisons between different rat strains and…

Design

Preclinical

Authors

GOGeorge OsolUniversity of Vermont WHW HalpernUniversity of Vermont

Discussion

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Implication

Animal data link vasomotion to genetic hypertensive strains; leaves open human relevance and clinical translation.

Structured PICO

Population

Resistance-sized branches of posterior cerebral arteries from Wistar-Kyoto (WKY), spontaneously hypertensive (SHR), spontaneously hypertensive stroke-prone (SHRSP), and antihypertensive-treated SHRSP (SHRSP-TRT) rats

Intervention

Stepwise increase in intravascular pressure (30 to 150-200 mmHg) and exposure to pharmacological agents (tetrodotoxin, indomethacin, ouabain, diltiazem, MnCl2, tetraethylammonium chloride) or cooling

Comparator

Comparisons between different rat strains (WKY vs SHR vs SHRSP vs SHRSP-TRT) and baseline/untreated states

Outcome

Myogenic tone (diameter reduction) and rhythmic vasomotion (presence, amplitude, frequency)surrogate

Rhythmic vasomotion in rat cerebral arteries appears to have a major genetic component linked to hypertensive strains, independent of blood pressure history.

Cite This Study

Osol et al. (1988) studied this question.

synapsesocial.com/papers/6a8d1d31b4e2d843785be414 https://doi.org/10.1152/ajpheart.1988.254.1.h28

Topics

Hypertension management

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Spontaneous vasomotion in pressurized cerebral arteries from genetically hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Spontaneous vasomotion in pressurized cerebral arteries from genetically hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider