Key result
Patients with dyslipidemia had significantly higher mean serum adenosine deaminase levels compared to healthy controls (35.22 vs 17.93 IU/L, p<0.001).
Why the study?
Elevated serum adenosine deaminase activity has been associated with dyslipidemia, but existing study results were inconsistent.
Does serum adenosine deaminase correlate with lipid profile parameters in patients with dyslipidemia?
Case-Control (n=60)
No
Does serum adenosine deaminase correlate with lipid profile parameters in patients with dyslipidemia?
Absolute Event Rate: 35.22% vs 17.93%
p-value: p=<0.001
While adenosine deaminase levels are elevated in patients with dyslipidemia, they do not significantly correlate with specific lipid profile parameters.
Elevated ADA in dyslipidemia cases shows no lipid correlation; hypothesis-generating and should not yet change practice.
Background: Dyslipidemia is becoming more common across all age groups mainly in young individuals because of imbalanced diets, low physical activity, and sedentary work culture. Several studies reported that elevated serum adenosine deaminase activity was associated with dyslipidemia, but the results were not consistent. Aim: It is aimed to correlate adenosine deaminase and lipid profile parameters in patients with dyslipidemia. Material and Methods: In this case-control study, a total of 60 subjects (30 diagnosed dyslipidemia patients and 30 age and gender-matched healthy individuals) were enrolled. Serum lipid profile parameters and adenosine deaminase levels were estimated in each subject. Results: The mean levels of lipid profiles, mainly triacylglycerol (TG), low-density lipoprotein-cholesterol (LDL-C), and adenosine deaminase, were found to be significantly high, while high-density lipoprotein-cholesterol (HDL-C) was found significantly low in cases than controls (p <0.001). adenosine deaminase has not shown any significant correlation with lipid profile parameters in patients with dyslipidemia and controls. Conclusion: The result showed that the serum adenosine deaminase and serum lipid profile levels were altered in patients with dyslipidemia.
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Yadav et al. (2024) conducted a case-control in Dyslipidemia (n=60). Dyslipidemia vs. Healthy controls was evaluated on Serum adenosine deaminase (ADA) levels (IU/L) (p=<0.001). Patients with dyslipidemia had significantly higher mean serum adenosine deaminase levels compared to healthy controls (35.22 vs 17.93 IU/L, p<0.001).
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