Why the study?
Does the addition of oleate or heparin-induced clearing factor alter the electrophoretic mobility of lipoproteins in human serum?
Population
n=6 human subjects and in vitro human serum samples.
Comparison
Intravenous heparin 0.75 mg/kg in vivo, and… vs Baseline/control plasma without heparin or oleate.
Design
Preclinical
Follow-up
1 hour
Authors
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Oleate binding alters lipoprotein mobility in vitro; leaves open any clinical relevance to heparin use or lipid risk modification today.
Does the addition of oleate or heparin-induced clearing factor alter the electrophoretic mobility of lipoproteins in human serum?
The study demonstrates that free fatty acids like oleate bind to alpha and beta lipoproteins, increasing their electrophoretic mobility, which explains the electrophoretic changes observed after heparin injection in lipemic subjects.
Robert S. Gordon (1955) studied this question.
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