Key result
Cardiac resynchronization therapy significantly improved mean left ventricular ejection fraction by 7.55% at 12 months compared to baseline.
Why the study?
The study aimed to correlate electrocardiographic, clinical, functional, and demographic parameters with LVEF improvement after CRT, and identify predictors to optimize patient selection and resynchronization strategy.
Does cardiac resynchronization therapy improve left ventricular ejection fraction in patients with heart failure, LBBB, and LVEF ≤35%?
Population
69 patients who underwent cardiac resynchronization therapy
Design
Single-center observational study
Follow-up
12 months
Authors
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Correlations of narrower post-CRT QRS, LVEDV, and ANP with LVEF gains are hypothesis-generating; leaves open prospective validation.
Cohort (n=69)
No
Does cardiac resynchronization therapy improve left ventricular ejection fraction in patients with heart failure, LBBB, and LVEF ≤35%?
Mean Difference: 7.55
p-value: p=0.001
Cardiac resynchronization therapy significantly improves left ventricular ejection fraction in patients with heart failure and LBBB, with baseline Q-LV interval and intraprocedural blood pressure increases serving as highly accurate predictors of echocardiographic response.
Rosu et al. (2024) conducted a cohort in Heart failure with major left bundle branch block and low ejection fraction (n=69). Cardiac resynchronization therapy (CRT) vs. Baseline was evaluated on Improvement in left ventricular ejection fraction (LVEF) at 12 months (7.55% increase, p=0.001). Cardiac resynchronization therapy significantly improved mean left ventricular ejection fraction by 7.55% at 12 months compared to baseline.
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