Key result
Current smoking was associated with lower adjusted 28-day case-fatality than never-smoking in hospitalized myocardial infarction patients (OR 0.71; 95% CI 0.56-0.90) and at the population level.
Why the study?
Does smoking status affect 28-day case-fatality in patients with myocardial infarction?
Observational (n=10,654)
Yes
Does smoking status affect 28-day case-fatality in patients with myocardial infarction?
Odds Ratio: 0.71 (95% CI 0.56–0.9)
Absolute Event Rate: 8.9% vs 20.1%
Current smoking is paradoxically associated with lower 28-day case-fatality in both hospitalized and population-level myocardial infarction patients, though among fatal cases, current smoking is marginally associated with a higher risk of out-of-hospital death.
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Smoking cessation advice should remain unchanged; observational data leave open residual confounding as explanation for lower MI case-fatality.
Elosúa et al. (2007) conducted an observational in myocardial infarction (n=10,654). Current smoking vs. Never-smokers was evaluated on 28-day case-fatality (OR 0.71, 95% CI 0.56-0.90). Current smoking was associated with lower adjusted 28-day case-fatality than never-smoking in hospitalized myocardial infarction patients (OR 0.71; 95% CI 0.56-0.90) and at the population level.
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