A method for determination of renin activity in dog's plasma and renal tissue

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Population

Healthy dogs (plasma and renal tissue)

Design

Preclinical

Authors

Discussion

Establishes baseline PRA in healthy dogs; leaves open translation to disease models or clinical use.

Population

Healthy dogs (plasma and renal tissue)

Intervention

Procedure for microdetermination of plasma renin activity using homologous substrate with incubation with Dowex 50W-X2 (NH4+) at pH 5.5 for 12 h

Outcome

Renin activity (nanograms of angiotensin formed per milliliter of plasma after 12 h of incubation)surrogate

Describes a method for measuring renin activity in dog plasma and renal tissue, establishing a baseline mean of 1.04 ng/ml per h in healthy dogs.

Granger et al. (1970) studied this question.

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