Why the study?
Does PD 155080 reduce blood pressure in rats with experimental chronic renal failure?
Population
Sprague-Dawley rats with experimental chronic renal failure and rats made hypertensive by continuous…
Comparison
PD 155080 (selective ET receptor antagonist)… vs Sham-operated rats
Design
Preclinical
Follow-up
7 days
Authors
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ET_A antagonism may lower BP in rat renal hypertension models without renal compromise; leaves open translation to human CKD.
Does PD 155080 reduce blood pressure in rats with experimental chronic renal failure?
ET-1 plays a role in established hypertension from reduced renal mass, and ET(A) receptor antagonism effectively lowers blood pressure without compromising renal function.
Potter et al. (1997) studied this question.
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