September 1, 1991Journal of Cardiovascular Pharmacology
Catecholamines and the Renin-Angiotensin-Aldosterone System During Treatment with Felodipine ER or Hydrochlorothiazide in Essential Hypertension
Why the study?
Does felodipine ER reduce blood pressure and alter neurohumoral responses differently than hydrochlorothiazide in patients with mild to moderate hypertension?
Population
28 patients with mild to moderate essential hypertension
Comparison
Felodipine extended release 10 mg once daily for… vs Hydrochlorothiazide 25 mg once daily for 2 weeks
Design
RCT, randomized, double-blind
Follow-up
2 weeks per treatment period
Authors
Discussion
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Implication
Felodipine ER may be preferred over HCTZ for BP control in mild-moderate hypertension; extends evidence on differential neurohumoral effects of CCBs versus diuretics.
Structured PICO
Does felodipine ER reduce blood pressure and alter neurohumoral responses differently than hydrochlorothiazide in patients with mild to moderate hypertension?
P
Population
28 patients with mild to moderate essential hypertension
I
Intervention
Felodipine extended release (ER) 10 mg once daily for 2 weeks
C
Comparator
Hydrochlorothiazide (HCTZ) 25 mg once daily for 2 weeks (crossover design)
O
Outcome
Blood pressure (systolic and diastolic) and neurohumoral responses (plasma norepinephrine, epinephrine, renin, and aldosterone)surrogate
Felodipine ER provides superior blood pressure reduction compared to low-dose hydrochlorothiazide in mild to moderate hypertension, despite causing a compensatory increase in sympathetic outflow.
Cite This Study
Köenig et al. (1991) studied this question.