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January 1, 1993Journal of Biological ChemistryOpen Access

Angiotensin II regulates parathyroid hormone-related protein expression in cultured rat aortic smooth muscle cells through transcriptional and post-transcriptional mechanisms.

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Why the study?

Does angiotensin II regulate PTHrP expression in cultured rat aortic smooth muscle cells?

Population

Cultured rat aortic smooth muscle cells (SMC)

Comparison

Angiotensin II vs Serum-deprived SMC without angiotensin II

Design

Preclinical

Authors

CPCarlos J. PirolaCedars-Sinai Medical CenterHWHuimin WangNational Chung Hsing UniversityAKA KamyarUniversity of Cincinnati Medical Center

Discussion

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Implication

Suggests a counter-regulatory vascular mechanism for angiotensin II; extends in vitro evidence but leaves open in vivo and clinical relevance.

Structured PICO

Does angiotensin II regulate PTHrP expression in cultured rat aortic smooth muscle cells?

P
Population
Cultured rat aortic smooth muscle cells (SMC)
I
Intervention
Angiotensin II
C
Comparator
Serum-deprived SMC without angiotensin II (implied control)
O
Outcome
PTHrP mRNA expression and gene transcriptionsurrogate

Angiotensin II increases PTHrP expression in vascular smooth muscle cells through transcriptional and post-transcriptional mechanisms, suggesting a local counter-regulatory role against vasoconstrictor effects.

Cite This Study

Pirola et al. (1993) studied this question.

synapsesocial.com/papers/6a8a5ee44c30e1095aecac01https://doi.org/10.1016/s0021-9258(18)53952-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease1979 · 22,197 citations
  2. 2Intrauterine occupancy controls expression of the parathyroid hormone-related peptide gene in preterm rat myometrium.1990 · 169 citations
  3. 3Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents.1988 · 271 citations
  4. 4A Parathyroid Hormone-Related Protein Implicated in Malignant Hypercalcemia: Cloning and Expression1987 · 1,308 citations
  5. 5SEQUENCES OF INTEREST: Gene-Encoding Parathyroid Hormone-Like Peptide: Nucleotide Sequence of the Rat Gene and Comparison with the Human Homologue1990 · 74 citations