Why the study?
Long-term durability is critical as TAV replacement extends to younger and lower-risk patients, and increased leaflet mechanical stress is a primary determinant of valve structural deterioration.
How do valve size, stroke volume, and degree of oversizing affect leaflet bending stress in self-expanding transcatheter aortic valves in an in vitro model?
How do valve size, stroke volume, and degree of oversizing affect leaflet bending stress in self-expanding transcatheter aortic valves in an in vitro model?
In vitro testing demonstrates that moderate transcatheter aortic valve oversizing increases leaflet bending stress, particularly in small annuli, potentially compromising long-term durability.
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Moderate oversizing was associated with higher leaflet bending stress in small annuli; leaves open effects on long-term TAV durability.
Stanová et al. (2020) studied this question.
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