Why the study?
Does the SAPIEN 3 TAVR model exhibit different stent and leaflet stresses compared to earlier SAPIEN generations in computational simulations?
Does the SAPIEN 3 TAVR model exhibit different stent and leaflet stresses compared to earlier SAPIEN generations in computational simulations?
Computational modeling indicates that the SAPIEN 3 TAVR valve experiences higher leaflet stress magnitudes and larger areas of high stress compared to earlier generations, which may predispose it to structural degeneration.
Higher stresses in S3 may predispose to structural degeneration; leaves open clinical durability implications.
Using computational simulations based on high-fidelity modelling of balloon-expandable TAVRs, our study demonstrated that maximum stress areas existed in similar leaflet locations across SAPIEN generations, while the latest model S3 had the highest magnitude for both 26- and 29-mm valves. S3 also had the largest area of higher stresses than other generations, which would be prone to degeneration. Our study coupled with future long-term clinical outcomes >10 years will provide insight on biomechanics of TAVR degeneration.
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Xuan et al. (2020) studied this question.
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