Why the study?
How do humoral and cellular immune responses to measles virus evolve over time in Cercopithecus aethiops monkeys?
Population
Cercopithecus aethiops monkeys
Design
Preclinical
Follow-up
at least 44 weeks
Authors
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Cellular measles immunity wanes rapidly in this primate model while humoral persists; leaves open translation to human vaccine strategies.
How do humoral and cellular immune responses to measles virus evolve over time in Cercopithecus aethiops monkeys?
In a monkey model of measles infection, humoral immunity persists long-term while cellular immunity wanes rapidly, becoming undetectable within 10 weeks.
Rustigian et al. (1975) studied this question.
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