Why the study?
Does add-on amlodipine improve functional and structural cardiovascular damage in hypertensive patients well controlled on an ARB?
Population
50 hypertensive patients whose blood pressure was already well controlled with an angiotensin II type 1…
Comparison
Add-on low-dose amlodipine for 12 months vs Placebo added to background ARB therapy
Design
Other
Follow-up
12 months
Authors
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May support vascular benefits of add-on amlodipine beyond BP control; hypothesis-generating and requires prospective confirmation.
Does add-on amlodipine improve functional and structural cardiovascular damage in hypertensive patients well controlled on an ARB?
Add-on low-dose amlodipine improves arterial stiffness and intima-media thickness in hypertensive patients already controlled on an ARB, independent of blood pressure lowering.
Ichihara et al. (2007) studied this question.
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