Why the study?
Does intravenous ouabain alter the pressor response to infused noradrenaline in patients with essential hypertension compared to normotensive subjects?
Population
32 subjects, comprising 16 normotensive subjects and 16 patients with essential hypertension.
Comparison
Intravenous injection of ouabain followed by… vs Normotensive subjects, and baseline measurements…
Design
Cross-sectional
Authors
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Attenuated ouabain effect on noradrenaline response in essential hypertension warrants no clinical action; leaves open endogenous Na/K-ATPase inhibitor role in low-renin cases.
Does intravenous ouabain alter the pressor response to infused noradrenaline in patients with essential hypertension compared to normotensive subjects?
Ouabain increases the pressor response to noradrenaline, suggesting that endogenous Na+,K+-ATPase inhibitors may contribute to the enhanced noradrenaline response seen in essential hypertension.
Nishimura et al. (1988) studied this question.
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