Why the study?
Does intraarterial ouabain infusion alter forearm vascular resistance differently in patients with essential hypertension compared to normotensive subjects?
Population
45 subjects, comprising 17 normotensive subjects and 28 patients with essential hypertension.
Comparison
Intraarterial infusion of the Na+,K+-ATPase… vs Control side and normotensive subjects.
Design
Cross-sectional
Authors
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May support compensatory Na+,K+-ATPase upregulation in mild hypertension; hypothesis-generating and requires prospective confirmation before clinical consideration.
Does intraarterial ouabain infusion alter forearm vascular resistance differently in patients with essential hypertension compared to normotensive subjects?
Increased activity of arteriolar Na+,K+-ATPase in mild essential hypertension may represent an early mechanism counteracting intracellular sodium accumulation.
Hulthén et al. (1984) studied this question.
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