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October 1, 1978Circulation ResearchOpen Access

Sites of action and active forms of lidocaine and some derivatives on cardiac Purkinje fibers.

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Population

Cardiac Purkinje fibers

Comparison

Lidocaine and its derivatives administered by… vs Lidocaine vs derivatives; extracellular vs…

Design

Preclinical

Authors

JGJerry GliklichColumbia UniversityBHBrian F. HoffmanBrunswick (United States)

Discussion

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Implication

Differentiates charged lidocaine actions by sarcolemmal surface in Purkinje fibers; hypothesis-generating for selective antiarrhythmics, warrants no practice change.

Structured PICO

P
Population
Cardiac Purkinje fibers
I
Intervention
Lidocaine and its derivatives (QX-314, QX-572, compound 6603) administered by superfusion (10(-5) and 10(-4) M) or iontophoretic intracellular injection
C
Comparator
Lidocaine vs derivatives; extracellular vs intracellular application
O
Outcome
Effects on transmembrane action potential (Vmax, phase 2 voltage, total action potential duration, phase 4 depolarization)surrogate

The antiarrhythmic effects of lidocaine and its derivatives on cardiac Purkinje fibers depend on the site of action (inner vs outer sarcolemma surface) and the charged state of the molecule.

Cite This Study

Gliklich et al. (1978) studied this question.

synapsesocial.com/papers/6a8a915c176d2ac34cfbe8b4https://doi.org/10.1161/01.res.43.4.638
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of lidocaine on the electrophysiological properties of ventricular muscle and Purkinje fibers1970 · 269 citations
  2. 2Effect of lidocaine hydrochloride on membrane conductance in mammalian cardiac purkinje fibers1972 · 89 citations
  3. 3Effects of a long-acting antiarrhythmic agent--QX-572--on therapy resistant ventricular tachyarrhythmias.1974 · 16 citations
  4. 4Effects of the quaternary ammonium compound OX-572 on ventricular tachyarrhythmias complicating acute myocardial infarction.1975 · 10 citations
  5. 5The permeability to tetraethylammonium ions of the surface membrane and the intercalated disks of sheep and calf myocardium1974 · 85 citations