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March 1, 1968European Journal of Endocrinology

EFFECT OF β-ADRENERGIC BLOCKADE ON FINGER TREMOR AND ACHILLES REFLEX TIME IN ANXIOUS AND THYROTOXIC PATIENTS

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Why the study?

Does intravenous dl-propranolol improve pulse rate, tremor, and Achilles reflex time in anxious and thyrotoxic subjects?

Population

Anxious and thyrotoxic subjects

Comparison

Intravenous dl-propranolol vs Inactive d-propranolol and saline alone

Design

Other

Authors

CMC. D. MarsdenBoston UniversityTGT. M. D. GimletteUniversity of LiverpoolRMR. G. McAllisterThe Graduate Center, CUNY

Discussion

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Implication

May support acute symptom relief with propranolol in thyrotoxicosis and anxiety; leaves open confirmation in randomized trials.

Structured PICO

Does intravenous dl-propranolol improve pulse rate, tremor, and Achilles reflex time in anxious and thyrotoxic subjects?

P
Population
Anxious and thyrotoxic subjects
I
Intervention
Intravenous dl-propranolol
C
Comparator
Inactive d-propranolol and saline alone
O
Outcome
Pulse rate, tremor amplitude, and Achilles reflex timesurrogate

Intravenous dl-propranolol effectively reduces pulse rate and tremor amplitude while prolonging Achilles reflex time in anxious and thyrotoxic patients.

Cite This Study

Marsden et al. (1968) studied this question.

synapsesocial.com/papers/6a8adfe31692ae2bc0f44ac1https://doi.org/10.1530/acta.0.0570353
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of atenolol, metoprolol, and propranolol on isoproterenol-induced tremor and tachycardia in normal subjects1981 · 31 citations
  2. 2Suppression of essential tremor by propranolol: Correlation of effect with drug plasma levels and intensity of beta‐adrenergic blockade1977 · 49 citations
  3. 3Effects of Autonomic Blockade on Heart Rate Responses to Reaction Time and Sustained Handgrip Tasks1988 · 29 citations
  4. 4HEMODYNAMIC EFFECTS OF ACUTE AND PROLONGED β‐ADRENERGIC BLOCKADE IN ESSENTIAL HYPERTENSION1974 · 112 citations
  5. 5Effects of propranolol on the impulse activity of cardiovascular sympathetic afferent fibers.1986 · 20 citations