Why the study?
Are reduced responses to atrial natriuretic factor in spontaneously hypertensive rats associated with a reduction in ANF binding sites?
Are reduced responses to atrial natriuretic factor in spontaneously hypertensive rats associated with a reduction in ANF binding sites?
The reduced effectiveness of atrial natriuretic factor in spontaneously hypertensive rats may be partly due to a reduction in ANF binding sites in the renal papilla and subfornical organ.
May contribute to ANF resistance in hypertensive rat models; leaves open relevance to human disease.
In the spontaneously hypertensive rat (SHR) as well as in the pathophysiological states with volume retention, high levels of atrial natriuretic factor (ANF) do not produce adequate diuresis and natriuresis. We have investigated the question whether the reduced effectiveness of ANF could be due to a reduction of the ANF binding. Evidence is provided by quantitative autoradiography with [125I]ANF than higher ANF plasma levels in SHRSP compared to normotensive WKY rats are associated with a reduced number of binding sites (25%) in the renal papilla as well as in the subfornical organ (69%). This could contribute to the reduced response of ANF in SHRSP.
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Agnati et al. (1988) studied this question.
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